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The disease spread into other areas, infected other tribes, and killed hundreds of thousands.
During this period, the powerful nations of the Iroquois Confederacy, based in New York, had maintained control of much of the Ohio Valley as hunting grounds by right of conquest after defeating other tribes.
The British and colonial force were defeated at Braddock's Field.
General John Forbes finally took the forks in 1758.
Fort Pitt is notable as the site of an early use of smallpox for biological warfare.
Lord Jeffrey Amherst ordered blankets contaminated from smallpox victims to be distributed in 1763 to the tribes surrounding the fort.
Today, Google, Apple, Bosch, Facebook, Uber, Nokia, Autodesk, and IBM are among 1,600 technology firms generating .7 billion in annual Pittsburgh payrolls.
After a public campaign the original spelling was officially restored by the United States Board on Geographic Names in 1911.The city features 30 skyscrapers, two inclined railways, a pre-revolutionary fortification and the Point State Park at the confluence of the rivers.The city developed as a vital link of the Atlantic coast and Midwest, as the mineral-rich Allegheny Mountains made the area coveted by the French and British empires, Virginians, Whiskey Rebels, and Civil War raiders.The French and Indian War, the North American front of the Seven Years' War, began with the future Pittsburgh as its center.British General Edward Braddock was dispatched with Major George Washington as his aide to take Fort Duquesne.